Welcome
The Zheng lab is devoted to obtaining a better understanding of the regulation and mechanisms of action of the Hedgehog (Hh) signaling pathway. The Hh signaling pathway is required for cell differentiation and organizes pattern formation in a variety of embryonic tissues. In the adult, Hh signaling remains active in some organs where it has been implicated in the regulation of stem-cell maintenance and proliferation. Hh pathway dysfunction thus can lead to embryonic pattern disruptions, such as holoprosencephaly and other birth defects in humans; post-embryonic dysfunction can result in failure of adult tissue regeneration as well as proliferative disorders, such as cancer.
The Zheng laboratory's primary research interest is in identifying target genes regulated by the Hh signal.
Explore a list of publications from the Zheng Lab.